Dr. Shaun Murphy, a young surgeon with autism and savant syndrome, continues to use his extraordinary medical gifts at St. Bonaventure Hospital's surgical unit. As his romantic relationship with Lea deepens, he will also face new responsibilities as a fourth-year resident, when he is put in charge of supervising a new set of residents that will test him in ways he cannot predict. Meanwhile, the team, must deal with the uncertainty and pressure that the Covid-19 pandemic brings now that it has hit their hospital.